Welcome to the  Garcia-Mata Lab.  We are a part of the Department of Biological Sciences at the University of Toledo.

    The research in the lab is centered in understanding the mechanisms of regulation of Rho family of small GTPases. Rho GTPases control many aspects of cell behavior, such as the organization of the cytoskeleton, cell migration, cell–cell and cell–matrix adhesion, cell cycle progression, gene expression and cell polarity.

 

Rho proteins act as molecular switches by cycling between an active (GTP bound) and an inactive (GDP bound) state. The activation of Rho proteins is mediated by specific guanine-nucleotide exchange factors (GEFs), which catalyze the exchange of GDP for GTP. In their active state, GTPases interact with high affinity with one of several downstream effectors to modulate their activity and localization. The signal is terminated by hydrolysis of GTP to GDP a reaction that is stimulated by GTPase activating proteins (GAPs). In addition, guanine nucleotide dissociation inhibitors (GDIs) negatively regulate Rho GTPases by sequestering Rho proteins and interfering with both the GDP/GTP exchange and the GTP hydrolysis 

    Current projects in the lab address the role of GTPases in podosomes and invadopodia formation, theregulation of Rho-GEFs by scaffolding proteins, and the function of RhoA in the nucleus.   

News

05/07/2016 20:20
We are changing our website, so please be patient if you can't find what you are looking for, or if it appear in weird places. We'll try to have it ready ASAP!
05/04/2016 10:49
Our review "I'm coming to GEF you: Regulation of RhoGEFs during cell migration" which appeared in Cell Adhesion and Migration, has recently been featured by the Journal as one of the most read of...
10/01/2015 08:44
We have just deposited our first plasmids at Addegene. Check for updates at the Garcia-Mata Lab Addgene page as our plasmid list should be growing in the near future.
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Contact

Rafael Garcia-Mata, PhD 3090 Bowman Oddy
Toledo, OH 43606
USA
419-530-1996 (office)
419-962-1991 (lab)
Rafael.GarciaMata@utoledo.edu