Welcome to the Garcia-Mata Lab                               at the University of Toledo

     Welcome to the Garcia-Mata Lab. We are a part of the Department of Biological Sciences at the University of Toledo.

    The research in the lab is centered in understanding the mechanisms of regulation of Rho family of small GTPases. Rho GTPases control many aspects of cell behavior, such as the organization of the cytoskeleton, cell migration, cell–cell and cell–matrix adhesion, cell cycle progression, gene expression and cell polarity.

    Rho proteins act as molecular switches by cycling between an active (GTP bound) and an inactive (GDP bound) state. The activation of Rho proteins is mediated by specific guanine-nucleotide exchange factors (GEFs), which catalyze the exchange of GDP for GTP. In their active state, GTPases interact with high affinity with one of several downstream effectors to modulate their activity and localization. The signal is terminated by hydrolysis of GTP to GDP a reaction that is stimulated by GTPase activating proteins (GAPs). In addition, guanine nucleotide dissociation inhibitors (GDIs) negatively regulate Rho GTPases by sequestering Rho proteins and interfering with both the GDP/GTP exchange and the GTP hydrolysis 

    Current projects in the lab address the role of GTPases in podosomes and invadopodia formation, theregulation of Rho-GEFs by scaffolding proteins, and the function of RhoA in the nucleus.   

News

Join the Impact Factor Insurrection; Sign DORA

05/22/2013 09:10
  Dear Colleagues   ASCB and a number of other scientific organizations and publishers have met over the last several months to discuss how we can combat the mis-use of journal impact...
>>

VOTE for our PICTURE!!!!!

04/18/2013 15:52
We have posted an immunofluorescence picture for the ATCC 2013 photo contest. You can see it HERE Please VOTE for it if you like it! We are in the TOP 10 right now but we want to get to the top!
>>

Oncogene article feature at NCI's site

03/29/2013 12:35
Our recently published article: "Palladin promotes invasion of pancreatic cancer cells by enhancing invadopodia formation in cancer-associated fibroblasts". Goicoechea SM, García-Mata R, Staub J,...
>>
1 | 2 | 3 | 4 >>

Search site

© Rafael Garcia-Mata 2009, All rights reserved.

Create free websites Webnode